Pharmacokinetics of Mycophenolic Acid in Kidney Trans
plant Recipients Treated with a Low Dose (1 gram/day) of
Mycophenolate Mofetil
WICHIAN JULASAREEKUL, MD*, SOMCHAI EIAM-ONG, MD**,
ORNANONG BEJRAPUTRA, BSc**, T ADA SEUBLINVONG, MD***
Affiliation : *Nephrology Unit, Medicine, Queen Sawangwatana Memorial Hospital, Chon Buri 20110,
**Division of Nephrology, Department of Medicine,
***Department of Biochemistry, Faculty of Medicine, Chulalongkom University, Bangkok 10330, Thailand.
AbstractPharmacokinetic studies of mycophenolic acid (MPA) were performed in 16 stable Thai
kidney transplant recipients treated with 1 g/d of mycophenolate mofetil (MMF). The complete area
under the blood concentration-time curve (AUC) of MPA was determined using the linear trapezoidal
rule from 8 concentrations at, 0, 1, 2, 3, 4, 6, 8, and 12 h after MMF administration. The mean values
of AUC were 37.54 ± 0.80 f.lg•h/ml. MPA concentrations at 8 h after dosing, not the trough or
0•12
maximum levels, showed the best correlation with AUCo. (r = 0.72). The equation model of abbre
12
viated AUC of MPA, derived by multiple linear regression analysis, that had the highest correlation
(r2 and lowest absolute prediction error (APE) was: AUC = 0.6 C + 1.9 C + 8.68 C + 4.65 (r2 = 0.92,
)
1 3 8
APE= 2.05 ± 0.32%). The best abbreviated AUC equations obtained by linear trapezoidal rule were :
AUC = 4.5 C + C + 1.5 C + 5 C (r2 = 0.78, APE= 5.78 ± 1.14%) and AUC = 5 Cl) + C + C + 5 C
0 1 2 4 1 2 3
(r2 = 0.76, APE= 6.21 ± 1.46%)
Keywords : Pharmacokinetic Studies, Mycophenolic Acid, Mycophenolate Mofetil
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