Corneal Lattice Dystrophy, a Concealed Ophthalmic Pro
blem in Thailandt
PINNITA PRABHASA WAT, MD*, SO MANUS THOONGSUWAN, MD*,
NATTAPORN TESAVIBUL, MD***, MONGKUL UIPRASERTKUL, MD**,
LA-ONGSRI ATCHANEEYASAKUL, MD*
Affiliation : *Department of Ophthalmology,
**Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700,
***Department of Ophthalmology, Pramongkutklao Hospital, Pramongkutklao Medical College, Bangkok 10300, Thailand.
t Presented in part at the 9'h Annual Meeting of the Royal College of Ophthalmologists of Thailand, July 26, 200 I and
in part at the 42,.. Siriraj Scientific Congress, March 5, 2002.
AbstractOne single family of corneal lattice dystrophy was examined and interviewed to elucidate the
variety of clinical manifestations, factors associated with visual impairment, and the impact on the
patient's quality of life.
Forty-three out of 88 family members (48.9%) were affected. The inheritance pattern was
autosomal dominant. Corneal haze grading from 1 to 4 was 5.3 per cent, 26.3 per cent, 43.4 per cent, and
25 per cent respectively. Surface irregularity grading from 1 to 4 was 18.4 per cent, 39.5 per cent, 32.9
per cent, and 9.2 per cent respectively. Forty-five per cent of the patients had VA::; 20/200. Corneal
haziness, irregularity, corneal erosion and disease duration were significantly related to visual impair
ment (p < 0.05). This disturbed the patient's activities such as reading (79.1 %), working (62.8%) and
daily life (69.8%).
Corneal lattice dystrophy within the same family may present with different manifestations
depending on the severity and duration of the disease and might be misdiagnosed. Inadequate know
ledge among patients was susceptible to the high prevalence of the disease leading to impaired quality
of life.
Keywords : Corneal Lattice Dystrophy, Corneal Dystrophy, Genetics Inheritance, Quality of Life,
Public Health Ophthalmology
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