Preliminary Experience of CyberKnife® Treatment of
Primary Non-Small Cell Lung Cancer
Thiti Swangsilpa MD*, Pornpan Yongvithisatid MSc*, Kumutinee Pairat MSc*, Patchareporn Dechsupa MSc*,
Mantana Dhanachai MD*, Somjai Dangprasert MD*, Ladawan Narkwong MD*, Chomporn Sitathanee MD*,
Putipun Puataweepong MD*, Parmon Puddhikarant MD*, Chuleeporn Jiarpinitnun MD*,
Patamintita Witoonpanich MD*, Taweesak Ukhumpun BSc*, Juthamat Khaophong BSc*
Affiliation :
* Radiation Oncology Division, Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
Objective : Provide the effectiveness of treatment protocol, radiotherapy plan, technique, and early clinical results of
inoperable primary non-small cell lung cancer (NSCLC) in patients who received CyberKnife® treatment at Ramathibodi
Hospital.
Material and Method: Six cases of inoperable primary NSCLC patients were evaluated for tumor response after having
received CyberKnife® treatment. The prescribed radiation dose was 45 gray (Gy) in three consecutive fractions for peripherally
located tumor and 50 Gy in five fractions within two weeks for centrally located tumor (biological equivalent dose, BED,
112.5 Gy10, and 100 Gy10, respectively). The response to treatment was evaluated from roentgenographic study during
follow-up period along with clinical outcome and adverse event.
Results : Overall response after the treatment was demonstrated in five cases with roentgenographic complete response
(CR, disappearance of tumor) and partial response (PR, 50% decrease in size) in two and three cases, respectively without
any severe adverse event. The treatment planning parameters demonstrated the effectiveness of radiation dose homogeneity
and conformity coverage of the target volume.
Conclusion : This preliminary report has provided the effectiveness of treatment plan and local tumor controlled without
severe adverse event for primary inoperable NSCLC patients receiving CyberKnife® treatment.
Keywords : CyberKnife®, Stereotactic body radiotherapy, Non-small cell lung cancer
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