Intracranial Germ Cell Thmors : Experience in King
Chulalongkorn Memorial Hospital
KANJANA SHOTELERSUK, MD*, PRA YUTH ROJPORNPRADIT, MD*,
TA YWIN CHOTTETANAPRASIT, MD*, CHAOWALIT LERTBUTSA YA NUKUL, MD*,
PRASERT LERTSANGUANSINCHAI, MD*, CHONLAKIET KHORPRASERT, MD*,
NOPADOL ASAVAMETHA,MD*, SIV ALEE SURlYA PEE, M.Eng*,
CHOTIKA JUMPANGERN, MSc**
Affiliation : * Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University.
** Division of Radiation Oncology, Department of Radiology, King Chulalongkorn Memorial Hospital, the Thai Red Cross
Society. Bangkok 10330, Thailand.
AbstractA retrospective study was performed on 69 patients with intracranial germ cell tumors who
were treated at the Division of Radiation Oncology, Department of Radiology, King Chulalongkorn
Memorial Hospital from 1990 to 2000. Median age was 15 years. Forty-two cases (60.87%) had histo
logically confirmed germinoma or nongerminomatous germ cell tumors. Germinoma was the predo
minate histology followed by mixed germ cell tumors. Pineal and suprasellar regions were the two lead
ing sites, hydrocephalus (85.5%) and diplopia (57.97%) were the two most common clinical presenta
tions. Only 13 cases had the result of cerebrospinal fluid (CSF) cytology or magnetic resonance imagine
(MRI) of the spine before initial treatment. Serum tumor markers, Alpha fetoprotein and f3-human
chorionic gonadotropin, were available in 66.67 per cent. Total or partial tumor removal were feasible
in 24 cases. Whole brain irradiation was given in almost all cases with the median dose of 3,600 cGy.
The median total tumor dose was 5,400 cGy. Whole spine radiation was utilized in 17 cases. The mean
follow-up time was 41 months. The five-year disease free survival was 73.59 per cent. Overall 3 and 5
year survival rates were 86.45 per cent and 81.64 per cent, respectively.
Keywords : Intracranial Germ Cell Tumors
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