Correlation of 4- and 24-hour Urine Protein in Women with Initially Diagnosed Hypertensive Disorders in Preg nancy
KITTI WONGKITISOPHON, MD*, VORAPONG PHUPONG, MD*, WARALAK YAMASMIT,MD*, PONGSAK PANSIN, BSc**, YUEN TANNIRANDORN, MD*, DHIRAPHONGS CHAROENVIDHY A, MD*
Affiliation : * Department of Obstetrics and Gynecology, ** Research Laboratory of Nephrology Unit, Department of Medicine,Faculty of Medicine, Chulalongkom University, Bangkok 10330, Thailand.
Objective : To determine whether 4-hour urine protein value correlates with 24-hour urine protein value in women with hypertensive disorders in pregnancy. Study
Design : Cross-sectional study was performed in 38 in-patient pregnant women who were initially diagnosed as having hypertensive disorders in pregnancy. Urine samples were collected within 24 hours in 2 successive periods: the first 4-hour and the next 20-hour urine, in separate con tainers. The urine volume, urine protein and creatinine concentrations were thus separately measured. The 4- and 24-hour urine proteins were calculated and the correlation between both groups was determined by simple linear regression analysis.
Results : A total of 38 patients were recruited into the study, 26 had mild preeclampsia, 5 had severe preeclampsia, and 7 had superimposed preeclampsia. The result of the 4-hour urine protein was found to correlate with those of the 24-hour urine protein for patients with hypertensive disorders in pregnancy (p < 0.001).
Conclusion : Total protein values of 4-hour samples positively correlated with values of 24-hour samples of patients with hypertensive disorders in pregnancy. This might be modified and used for urine protein collection in outpatients to improve the compliance.
Keywords : Preeclampsia, Superimposed Preeclampsia, Proteinuria, 4-hour Urine, 24-hour Urine
