Comparison of Topical Prednisolone Acetate, Ketorolac Tromethamine and Fluorometholone Acetate in Reducing Inflammation after Phacoemulsification
ADISAK TRINAVARAT,MD*, LA-ONGSRI ATCHANEEYASAKUL, MD*, THAMMANOON SURACHATKUMTONEKUL, MD*, PANIDA KOSRIRUKVONGS, MD*
Affiliation : * Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Method : One hundred and twenty eyes were enrolled in a prospective, investigator-masked, randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data were recorded weekly: visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells and flare in the anterior chamber, and ocular symptoms.
Results : The number of eyes with a minimal amount of cells in the anterior chamber in the = ketorolac group was less than the prednisolone group on day 7 (11:20, p 0.008) and day 14 (23:31, = p = 0.015), and than fluorometholone group on day 7 (11:21, p 0.011). Intraocular pressure in the = prednisolone group was higher than the ketorolac group on day 21 (14.6: 12.2 mmHg, p 0.016). One eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported frequently in the ketorolac group.
Conclusion : All 3 drugs were effective in reducing post-operative inflammation. The effi cacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.
Keywords : Prednisolone Acetate, Ketorolac Tromethamine, Fluorometholone Acetate, Phaco emulsification
