Newborn Screening for Congenital Hypothyroidism in
Khon Kaen University Hospital, the First Three Years, A
Preliminary Report
OUYPORN PANAMONTA, MD*, SUKANYA TUKSAPUN, MD*,
PAKAPHAN KIATCHOOSAKUN, MD*, JUNY A JIRAPRADITTHA, MD*,
WICHITR KIRDPON, PhD**, MALINEE LOAPAIBOON, PhD***
Affiliation : * Department of Pediatrics,
** RIA Laboratory Unit, Faculty of Medicine, Srinagarind Hospital,
*** Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002,
Thailand.
AbstractBetween January 2000 and December 2002, 9,558 of 10,868 live births at Srinagarind Hospi
tal, Khon Kaen University, Khon Kaen, Thailand, were screened for congenital hypothyroidism (CH).
Dried blood spot thyroid stimulating hormone (TSH) was collected at age 48 hours or older. The cut-off
TSH level for recall test was> 25 mulL. Serum thyroxine (T4), Free T4 and TSH were performed during
the confirmatory test. Six of 24 infants recalled for confirmatory thyroid function tests had abnormal
tests. Primary CH was confirmed in 3 infants and thyroxine treatment was given. Two of the three infants
had thyroid dysgenesis, one had normal thyroid gland. Three infants showed borderline CH from the
confirmatory test, only one had borderline CH from the second confirmatory test and also received
thyroxine treatment. Twenty infants with false positives during the screening and confirmatory tests were
regularly followed-up for growth, development and thyroid function tests. The incidence of primary CH
in this sole tertiary care government hospital in Northeast Thailand was 1 : 3,186. Routine newborn CH
screening would ensure early detection and treatment.
Keywords : Congenital Hypothyroidism, Newborn Screening, Borderline Hypothyroidism, Thailand
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