Relationship between Human Papilloma Virus Infection
and Abnormal Pap Smear in HIV-Seropositive Women at
Siriraj Hospital
KORAKOT SIRIMAI, MD*, PAVIT SUTCHRITPONGSA, MD*,
PONGSAKDI CHAISILWATTANA, MD*, KWA NJIT LAOTHONG, BSc*
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700,
Thailand.
AbstractThe purpose of this prospective study was to determine the prevalence of human papilloma
virus and abnormal Pap smear in HIV -seropositive women, particularly in HIV -seropositive women
who undertook antiretroviral drug. The consecutive series of 178 HIV -seropositive women was enrolled
in the Department of Obstetrics and Gynecology, Siriraj Hospital. All general information and labora
tory results of the patients were recorded. Pap smears are obtained from the endocervix, cervical trans
formation zone and vagina by using a cotton tip stick and Ayre spatula, as described in the VCE tech
nique. The patients were assigned into two groups, the AZT and non-AZT group. The comparison
between the groups was calculated statistically.
It was found that 88 of 178 HIV-seropositive women (49.4%) undertook Zidovudine. The
prevalence of abnormal Pap smear in HIV -seropositive women, who had an abnormal Pap smear, was
59.6 per cent. However, the prevalence of human papilloma virus infection detected by Pap smear was
reported in 17 patients (9.6% ). There was no difference between the AZT and non-AZT group statis
tically. There was a significantly higher probability of finding an abnormal Pap smear for cervical
dysplasia in HIV -seropositive women who were infected with human papilloma virus compared to.
It is concluded that there is a higher risk of developing cervical dysplasia in HIV -seroposi
tive women who carry the human papillomavirus.
Keywords : Human Papillomavirus, Abnormal Pap Smear, Human Immunodeficiency Virus
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