The Preemptive Analgesic Effect of Celecoxib for Day Case Diagnostic Laparoscopy

PITCHA PHINCHANTRA, MD* SUVIT BUNYAVEHCHEVIN, MD, MHS*, SOMCHAI SUW AJANAKORN, MD*, WIRACH WISA WASUKMONGCHOL, MD*

Affiliation : *Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkom University, Bangkok 10330, Thailand.

AbstractIn a randomized trial, the preemptive analgesic effect of celecoxib in 110 infertile women undergoing day-case diagnostic laparoscopy was studied at King Chulalongkom Memorial Hospital, Bangkok, Thailand. The patients randomly received either 200 mg celecoxib or placebo orally 2 hours before diagnostic laparoscopy. The post-operative shoulder pain and wound pain were self assessed and recorded, using Visual Analogue Scores (VAS) at 1, 2, 4, 12, and 24 hours. Total post-operative anal gesic requirements were recorded at 24 hours. The mean Visual Analogue Scores (VAS) of shoulder = pain in celecoxib group was statistically lower than those of the placebo group (p 0.04 ). Nevertheless, the mean VAS of wound pain and the total post-operative analgesic requirements were not significantly different. It was concluded that the preemptive celecoxib in day-case diagnostic laparoscopy might have the advantage of decreasing post laparoscopic shoulder pain.

Keywords : Celecoxib, Diagnostic Laparoscopy, Analgesic Effect

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