Mammographic Change in Hysterectomized Women on 0.625 mg/day of Conjugated Equine Estrogen
ATAPORN PANPANIT, MD*, MALA I MUTTARAK, MD**, SAIPIN PONGSA THA, MD*, SOMSAK CHAOVISITSAREE, MD*, WIRA WIT PlY AMONGKOL, MD*, SOMPONG TRUENGTHAWATCHAI, MD*, NUNTANA MORAKOT, MSc*, NARISA SRIBANDITMONGKOL, BSc*, SUPRANEE NOI-UM, BSc*, KUNNIKA CHURITH, BSc*, MALINEE CHUNTA RANIKUL, BSc*
Affiliation : * Department of Obstetrics and Gynecology, **Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand.
Objective : To compare the mammographic change before and after conjugated equine estrogen (CEE) 0.625 mg/day in hysterectomized women.
Design : A retrospective descriptive study.
Setting : Menopause clinic, Maharaj Nakorn Chiang Mai Hospital.
Materials and Methods : Dedicated mammograms and demographic data of 66 women who had been hysterectomized were reviewed. Post surgical menopausal women were recruited for the study. CEE 0.625 mg/day was given just after the operation. The baseline mammography was done before the initiation of HRT and they were compared with the follow-up mammography performed 12-18 months after therapy. The degree of increase in mammographic density was classified as follows: minimal changes (10-25% increased density), moderated change (26-50% increased density), and marked change (>50% increased density).
Results : The mean age± SD was 47 ± 4.3 years old. The mean duration± SD of hormone used was 13.5 ± 2.4 months. The most common indication for operation was myoma uteri (43.9%). On the baseline mammogram, 5 cases had cystic change and one case had a small circumscribed solid mass suspected to be fibroadenoma. On the follow-up mammograms, there were 2 cases (3.0%) detected to have significantly increased breast density. One was moderately increased and the other was markedly increased, but cystic changes and one fibroadenoma were not changed.
Conclusion : CEE has little effect on increased mammographic density.
Keywords : Mammographic Change, Hysterectomized Women, Hormone Replacement Therapy
