Candida Species, Genotypes and Antifungal Susceptibility
of Candida Isolates from Blood Samples of Patients at the
Largest Tertiary Care Hospital in Thailand During 1999-
2002
SUPORN FOONGLADDA, DVM, PhD*, PIYAPORN SAKULMAIWATANA, MSc*,
PORNPHAN PETLUM, BSc*, NIRAN VA NPRAPAR, MD, MSc**
Affiliation : * Department of Microbiology,
**Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractFrom 1999 to 2002, a total of 202 Candida isolates causing candidemia were recovered from
202 individual patients in the largest tertiary hospital in Bangkok, Thailand. C. albicans comprised 44.55
per cent of all isolates. Non-albicans Candida spp. isolates accounted for 55.45 per cent of all candi
demia episodes and were primarily due to C. tropicalis (45%) followed by C. parapsilosis (6%), C.
glabrata (4%), and C. krusei (0.5l7o). Non-albicans Candida spp appeared more frequently in children
(59%). Regarding etiology, non-albicans Candida spp showed an increase (67%) in the year 2002. The
distribution of C. albicans genotypes was as follows: genotype A, 71 per cent; genotype B, 26 per cent
and genotype C, 3 per cent, with a similar susceptibility proportion to amphotericin B, fluconazole and
itraconazole. All isolates of C. albicans, C. tropicalis, and C. parapsilosis were susceptible to fluco
nazole in vitro. Only 16.7-19.8 per cent of the isolates were resistant to itraconazole. A high proportion
of C. glabrata isolates showed drugs resistance.
Keywords : Candidemia, Candida species, Genotypes, Drug Susceptibility
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