Intra-Articular Injection of Deproteinized Hemodialysate in Osteoarthritis of the Knee : A Case-Series
VILAI KUPTNIRAT SAIKUL, MD*, SOMSAK KUPTNIRA TSAIKUL, MD**
Affiliation : *Department of Rehabilitation Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ** Department of Orthopedic Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Objective : To report the efficacy of intra-articular injection of deproteinized hemodialysate including its side effects in a case-series of knee osteoarthritic (OA) patients.
Materials and Methods : Intra-articular injection of deproteinized hemodialysate was per formed in 17 subjects (3 male and 14 female) with primary knee OA. Their average age was 63 years (min, max= 50,80 yrs). The X-ray appearance was grade II-III according to Kellgren-Lawrence criteria.
Measurements : 100 mm visual analogue scale (VAS) and any side effects.
Results : The mean (95% CI) of the VAS before and after injection were 70.0 (59.9-80.1) and 42.7 (31.2-54.2) respectively, with a p-value of< 0.001. The mean difference in pain score was 27.35 (95% CI = 17.0-37.7). The symptoms of knee pain resolved in an average of 4.8 (2.9) days (min, max = 1, 10). No side effects were found.
Conclusion : Intra-articular injection of deproteinized hemodialysate is effective and safe. However, a further controlled trial with an adequate sample size should be performed to confirm the efficacy as well as to detect any adverse effects of this drug.
Keywords : Intra-Articular Injection, Deproteinized Hemodialysate, Knee Osteoarthritis, Case-Series
