Prediction of CIN3+ in LEEP Specimen by Preoperative Inflammatory Markers
Thapanop Thanasomthopchanamon¹, Pattra Wisarnsirirak¹, Thaya Akarawat¹, Kanokwan Promchit¹, Awassada Punyashthira¹, Nopwaree Chantawong¹, Karicha Mairaing¹, Yuthadej Thaweekul¹, Yenrudee Poomtavorn¹, Junya Pattaraarchachai², Komsun Suwannarurk¹
Affiliation : ¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand; ² Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand
Objective: To identify preoperative inflammatory markers for predicting lesion of CIN3+ in individuals who underwent loop electrosurgical excision procedure (LEEP).
Materials and Methods: The present study was a retrospective study conducted at the Gynecologic Oncology unit, Thammasat University Hospital (TUH), Thailand. The study period was between 2018 and 2023. Participants were subjects who underwent LEEP at TUH. Preoperative complete blood count (CBC) was obtained for calculation of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammatory response index (SIRI). The data were collected from digital records and analyzed.
Results: Ninety-eight subjects were recruited. Mean age of participants was approximately 43 years old. Two-thirds (62 out of 98) of the subjects were diagnosed with CIN3 or cervical cancer from LEEP histopathology. The combination of the inflammatory markers, including NLR, PLR, and SIRI provided prediction of CIN3+ lesions with sensitivity and positive predictive value of 93.5% and 63.7%, respectively.
Conclusion: The combination of NLR, PLR, and SIRI could predict CIN3+ lesions in patients who underwent LEEP.
Received 10 February 2025 | Revised 15 September 2025 | Accepted 22 September 2025
DOI: 10.35755/jmedassocthai.2025.12.946-950-02750
Keywords : Cervical cancer; CIN; LEEP; Inflammatory markers
