Incidence and Risk Factors for Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)-Related Rash in Thai Children with HIV Infection
Sunitha Vemula MD*, Stephen Kerr MD**, Chitsanu Pancharoen MD***, Arida Siripong MD**, Pope Kosalaraksa MD****, Chulapan Engchanil MD****, Arpa Chuamchaitrakool MD**, Jintana Intasan MD**, Pagakrong Lumbiganond MD****, Praphan Phanuphak MD**, Jintanat Ananworanich MD**
Affiliation : * Washington University, St. Louis, USA ** The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT) and The Thai Red Cross AIDS Research Center, Bangkok, Thailand *** Chulalongkorn University, Bangkok, Thailand **** Khon Kaen University, Khon Kaen, Thailand
The present study evaluated the incidence and risk factors that correlated with the development of non-nucleoside reverse transcriptase inhibitor (NNRTI) related rash in 69 Thai children followed prospec- tively. The overall incidence of NNRTI-related rash was 16% (22% for NVP and 4% for EFV rash). The only significant predictive factor that correlated with the development of NNRTI-related rash in a multivariate logistic regression model was a CD4% decrease at week 12.
Keywords : NNRTI, Rash, Children, NVP, EFV, HIV
