The Immunological Response of Thai Infants to Haemophilus influenzae Type B Polysaccharide-Tetanus Conjugate Vaccine Co-administered in the Same Syringe with Locally Produced Diphtheria-Tetanus-Pertussis Vaccine
Angkool Kerdpanich MD*, Yanee Hutagalung MD**, Veerachai Watanaveeradej MD*, Hans L Bock MD**, Mark Steinhoff MD***
Affiliation : * Infectious Diseases Unit, Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand ** GlaxoSmithKline Biologicals, Rixensart, Belgium *** Johns Hopkins University, Baltimore, USA
Objective : Comparing the immunogenicity and reactogenicity of three vaccine combinations. These were
GlaxoSmithKline Biologicals’ (GSK) Haemophilus influenzae type b vaccine (Hib-TT; Hiberix™) administered
with the local Government Pharmaceutical Organization’s (GPO) diphtheria-tetanus-pertussis whole cell
(DTPw) vaccine, Hib-TT mixed with GPO’s DTPw vaccine, or Hib -TT mixed with GSKs’ DTPw vaccine
(Tritanrix™.
Materials and Methods : An open, randomized, controlled, single center study of three hundred and sixty
infants. They were randomized into three groups to receive either Hib-TT; Hiberix™ mix with GPOs’ DTPw
vaccine (group 1), Hib-TT mixed with GPO’s DTPw vaccine (group 2), or Hib -TT mixed with GSKs’ DTPw
vaccine (Tritanrix™; group 3) at two, four and six months of age.
Result: One month after the third dose, all subjects had antibodies level against Hib polyribosylribitol phos-
phate (PRP) > 0.15 mg/ml. All subjects except two (in group 2) had anti-PRP levels > 1.0 mg/ml. The geometric
mean concentrations were similar in all three groups. Over 96% of the subjects in all three groups demon-
strated an immunological response to diphtheria, tetanus, and pertussis antigens. There was no difference
among the three groups in terms of severe local reaction and fever.
Conclusion : The present study showed that the combined vaccines produced an effective antibody response
with no increase in reactogenicity compared to separately administrated vaccines.
Keywords : Combined vaccine, Haemophilus influenzae, Immunogenicity, DTPw
