The Comparison of Montgomery and Asberg Depression Rating Scale (MADRS Thai) to Diagnostic and Statistical Manual of Mental Disorders (DSM) and to Hamilton Rating Scale for Depression (HRSD): Validity and Reliability
Sirina Satthapisit MD*, Naiyana Posayaanuwat MD**, Chadapim Sasaluksananont MD***, Titawee Kaewpornsawan MD***, Supachoke Singhakun MD***
Affiliation : * Division of Psychiatry, Saraburi Hospital, Saraburi ** Division of Psychiatry, Phang-nga Hospital, Phang-nga *** Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Bangkok
Objective : To assess the validity and reliability of the Montgomery and Asberg Depression Rating Scale
(MADRS Thai) by comparing DSM-IV TR criteria and Hamilton Rating Scale for Depression (HRSD).
Materials and Methods : Descriptive study. Subjects were recruited from the psychiatric out-patient clinic
Siriraj Hospital. Subjects were assessed by MADRS Thai version and clinical interview.
Validity: Opinion from psychiatric and social science experts, evaluating 13 study cases and 27 control cases,
compared to the Global Assessment Scale (GAS) and to the changed scale of HRSD.
Reliability: Inter-rater and Intra-rater reliability and Internal consistency.
Results : Content validity is above 0.5 except the item of Inner tension, Lassitude and Inablilty to feel. Criterion
validity when compared to DSM-IV TR or HRSD, the sensitivity, specificity, PPV and NPV were all 100%.
Pearson correlation coefficients sensitive to change were -0.49 (p -value = 0.11) and 0.679 (p-value = 0.025)
when compared to 1) DSM-IV TR and 2) HRSD, respectively. ICC of Inter-rater and Intra-rater reliability were
both 0.99 when compared to either 1) DSM-IV TR or 2) HRSD. Cronbach’s alpha of Internal consistency was
0.96 and 0.92 when compared to 1) DSM-IV TR and 2) HRSD, respectively.
Conclusion : The result suggested that the Thai version of the Montgomery and Asberg Depression Rating
Scale had a very good validity and reliability. Therefore, it can be used as a diagnostic test in Thai depressed
patients.
Keywords : Montgomery and Asberg Depression Rating Scale -Thai, DSM-IV TR, Social function
