The Effect of Pre-Pregnancy Weight on Delivery Outcome and Birth Weight in Potential Diabetic Patients with Normal Screening for Gestational Diabetes Mellitus in Siriraj Hospital
Nisarat Phithakwatchara MD*, Vitaya Titapant MD*
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University
Objective : To investigate the influence of pre-pregnancy weight on delivery outcome and birth weight in
potential diabetic women with normal glucose tolerance.
Design : Retrospective Cohort study
Materials and Methods : The medical records of 660 pregnant women, who attended the antenatal clinic and
delivered at Siriraj Hospital between January 2003 and December 2005, were reviewed and analyzed. They
all had the known pre-pregnancy weight and were at risk of gestational diabetes with the normal glucose
tolerance. Any pregnant women without pre-pregnancy weight recorded were excluded from the present
study. They were classified into two groups according to the pre-pregnancy BMI, one was the overweight
group (BMI > 27 kg/m2) and the other was the normal weight group (BMI 20-25 kg/m2). Information of the
complications of pregnancy, the route of delivery, birth weight, and neonatal outcomes were collected and
analyzed.
Results : The risks of adverse pregnancy outcomes in overweight women, after adjusting for the confounding
factors, were significantly increased, including pre-eclampsia (OR 3.87, 95%CI 2.09-7.25, p < 0.001), cesarean
delivery (OR 2.22, 95%CI 1.45-3.39, p < 0.001), cephalopelvic disproportion (OR 2.15, 95%CI 1.35-3.42,
p = 0.001), and macrosomia (OR 7.59, 95% CI 1.98-29.09, p < 0.001).
Conclusion : Even though the screening test for gestational diabetes mellitus is normal, the overweight women
still have several adverse pregnancy outcomes.
Keywords : Birthweight, Delivery outcome, Normal glucose tolerance, Overweight, Pregnancy
