Prevalence of BRCA1 Expression in Epithelial Ovarian Cancer: Immunohistochemical Study
Nakarin Sirisabya MD*, Tarinee Manchana MD*, Wichai Termrungreunglert MD*, Surang Triratanachat MD*, Navapun Charuruks MD*, Damrong Tresukosol MD*
Affiliation : * Department of Obstetrics and Gynecology,Faculty of Medicine,Chulalongkorn University
The 99 formalin fixed paraffin-embedded ovarian tissue specimens of Epithelial Ovarian Cancer(EOC) patients treated at the Gynecologic Oncology Unit, King Chulalongkorn Memorial Hospital between January 1, 1996 and December 31, 1999, were immuno-stained with BRCA1 antibody using the immunohistochemical method. According to the criteria for BRCA1 immunohistochemical evaluation (neoplastic nuclear staining more than 10%), 12 (12.1%) of the 99 specimens showed positive BRCA1 expression. No associated statistical significance between clinicopathological variables and BRCA1 expression was detected. Survival analysis was performed in 87 patients who were followed-up for more than 6 months and recent status were available. During a median follow-up of 43 months, median survival time was 46 months (range 6-84 months). No association between BRCA1 expression and survival outcomes was found (Disease free survival and overall survival) in the presented patients.
Keywords : BRCA1, Ovarian cancer, Immunohistochemistry
