Outcome of Idiopathic Thrombocytopenic Purpura in Pregnancy in King Chulalongkorn Memorial Hospital
Sukrutai Nisaratanaporn MD*, Nares Sukcharoen MD*
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University
Objective : To study the maternal and fetal outcome of idiopathic thrombocytopenic purpura (ITP) in preg-
nancy.
Materials and Methods : The medical records of women who were diagnosed to be idiopathic thrombocytopenic
purpura during and before pregnancy from January 1995 to December 2004 were reviewed.
Results : There were 33 pregnancies from 29 ITP women as four women had two pregnancies each and one was
twins. Nine cases (27.3%) were active ITP, five cases (15.2%) were relapsing ITP and eight cases (24.2%) were
inactive ITP. Eleven cases (33.3%) had severe thrombocytopenia during delivery and five neonates (23.8%)
had severe thrombocytopenia. There was no statistical correlation between maternal and neonatal platelet
concentration (r = -0.0601). None of the mothers and fetuses had serious hemorrhagic complication such as
intracranial hemorrhage.
Conclusion : There were low hemorrhagic risks in both mothers and infants because of the constant monitoring
of multidisciplinary groups of experienced physicians, including obstetricians, hematologists, anesthesiolo-
gists and neonatologist.
Keywords : Idiopathic thrombocytopenic purpura (ITP), Immune thrombocytopenia, Neonatal thrombocy- topenia
