Bedside Renal Assessment: A Comparison of Various Prediction Equations in Thai Healthy Adults
Charoen Kaitwatcharachai MD*
Affiliation : * Division of Medicine, Hat-Yai Hospital, Hat Yai, Songkhla
Objectives : To compare the performance of various prediction equations for creatinine clearance (CrCl) and
glomerular filtration rate (GFR) estimation in healthy Thai adults.
Materials and Methods : 60 healthy adults had urine analysis, serum creatinine and 24-hour urinary creatinine
assessment. The author compared Cockcroft-Gault (CG), MDRD, and Rule equations, and that using urine-
CrCl for estimation of GFR.
Results : The urine-CrCl was 105.3 (cid:31) 39.3 ml/min/1.73 m2. The CrCl/GFR using CG and MDRD equations were
significantly lower than urine-CrCl. There was considerable difference between the stratification of renal
function with the various formulae. According to both equations, the incidence of subjects with CrCl/GFR of
< 90 ml/min/1.73 m2 was about 60%. R2 reflecting the degree of correlation between estimated CrCl/GFR and
the urine-CrCl was weak.
Conclusion : The performance of the CG and MDRD equations were suboptimal for renal function assessment
in Thai healthy adults. Further research is required to develop more reliable methods for estimating GFR
across different ethic groups.
Keywords : Glomerular filtration rate, Creatinine clearance, Prediction equations, Normal healthy Thai adults, Cockcroft-Gault equation, MDRD equation
