Thailand Diabetes Registry Project: Prevalence and Risk Factors of Stroke in Thai Diabetic Patients
Nattachet Plengvidhya MD*, Rattana Leelawatana MD**, Thongchai Pratipanawatr MD***, Chaicharn Deerochanawong MD****, Sirinate Krittiyawong MD*****, Pongamorn Bunnag MD******, Nattapong Kosachunhanun MD*******, Sompongse Suwanwalaikorn MD********, Yupin Benjasuratwong MD*********, Thanya Chetthakul MD**********, Chadpraorn Ngarmukos MD******, Sathit Vannasaeng MD*, Sirima Mongkolsomlit BS***********, Chulaluk Komoltri PhD************, Petch Rawdaree MD*************
Affiliation : * Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University ** Department of Medicine, Faculty of Medicine, Prince of Songkla University *** Deptpartment of Medicine, Faculty of Medicine, Khon Kaen University **** Rajavithi Hospital, ***** Theptarin General Hospital ****** Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University ******* Department of Medicine, Faculty of Medicine, Chiang Mai University ******** Department of Medicine, Faculty of Medicine, Chulalongkorn University ********* Department of Internal Medicine, Phramongkutklao Hospital ********** Department of Medicine, Maharat Nakhon Ratchasima Hospital, *********** TDR research coordinator ************ Division of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University
************* BMA Medical College and Vajira Hospital
Objective : To determine the prevalence of stroke and its risk factors in Thai diabetic patients who attended the
diabetes clinics of university and tertiary-care hospitals.
Materials and Methods : A cross-sectional, multi-center, hospital-based diabetes registry was carried out at
diabetes clinics of 11 university and tertiary-care hospitals. Demographic data, clinical characteristics,
common drugs used and laboratory parameters were analyzed for prevalence and risk factors associated with
stroke.
Results : The prevalence of stroke in the patients studied was 3.5%. Most of the patients were type 2 diabetes
and had ischemic stroke. One of the risk factors associated with stroke was age greater than 60 years, and the
risk appeared to be highest if the patients’ age was greater than 70 years (adjust OR = 3.29, p = 0.012). Other
risk factors included male sex, systolic blood pressure of > 140 mmHg, use of oral hypoglycemic agents, lipid
lowering agents and aspirin. There was no association between stroke and duration of diabetes, occupation,
educational level, BMI, smoking, alcohol drinking, diastolic blood pressure, use of antihypertensive drugs or
insulin, glycemic control, lipid profiles and kidney function.
Conclusion : Ischemic stroke was common among Thai patients with diabetes especially in the elderly. The
present result emphasizes the relationship between level of systolic blood pressure and the occurrence of
stroke. Optimal blood pressure control should be underscored in caring for diabetic patients.
Keywords : Diabetes, Diabetes Registry Stroke, Systolic Blood Pressure
