Relationship of Body Composition and Circulatory Adiponectin to Bone Mineral Density in Young Premenopausal Women
Suwannee Chanprasertyothin MSc*, Sunee Saetung MSc**, Penpan Payattikul MSc*, Rajata Rajatanavin MD**, Boonsong Ongphiphadhanakul MD**
Affiliation : * Research Center, Ramathibodi Hospital, Mahidol University ** Department of Medicine, Ramathibodi Hospital, Mahidol University
Objective : Adiponectin is a recently discovered hormone secreted by adipocytes. Adiponectin plays an impor-
tant role in the regulation of insulin sensitivity as well as the propensity to inflammation and atherosclerosis.
In the present study, the authors explore the relationship between adiponectin and bone mass in premeno-
pausal women. The relationship of fat mass compared to lean body mass to bone mass was also investigated.
Materials and Methods : Two hundred premenopausal women aged between 20 and 40 years were studied. Bone
mineral density (BMD) was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA).
Serum adiponectin concentrations were measured by radioimmunoassay.
Results : At the lumbar spines, factors associated with BMD were age (p < 0.01) and lean body mass (p <
0.001). No independent association with fat mass was demonstrated. Likewise, at the femoral neck, only lean
body mass was related to BMD (p < 0.01). In terms of the relation of serum adiponectin to BMD, no association
of serum adiponectin to BMD at the lumbar spines or femoral neck was found.
Conclusion : Altogether, the present findings do not suggest the independent role of adiponectin in the accrual
of bone mass in females, although such a role still cannot be excluded in men or postmenopausal women.
Keywords : Adiponectin, BMD, Premenopausal, Body composition
