Effects of Biphasic Oral Contraceptives Containing Desogestrel (Oilezz(cid:31)) on Cycle Control Facial Acne and Seborrhea in Healthy Thai Women
Naroemit Wonglikhitpanya MD*, Surasak Taneepanichskul MD*
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicince, King Chulalongkorn Memorial Hospital, Chulalongkorn University
Objective : To demonstrate the effects of a new biphasic oral contraceptive (Oilezz(cid:31)) on cycle control as well as
mild to moderate acne and facial seborrhea of healthy fertile Thai women.
Materials and Methods : The trial is a prospective, open, non-comparative, single center study. Fifty healthy,
fertile Thai women with mild to moderate facial acne were recruited to study a specific drug (Oilezz(cid:31)) for 6
months.
Results : At the beginning, 66% of the subjects had mild acne and 34% had moderate acne. Significant
improvements in facial seborrhea grades (as indicated by Sebutape assessments) were found after the first
cycle. These improvements increased steadily and were much larger after the sixth cycle. There were no
statistically significant changes in body weight or blood pressure during the study. No serious adverse events
were reported. There were no mood changes, migraine, rash, abdominal discomfort, malaise, nausea and
decrease in libido during the study period. The premenstrual symptoms at initiation were 21 cases (42%). The
symptoms were 4 (8%) with headache, 8 (16%) with breast tenderness, 5 (10%) with dysmenorrhea and one
(2%) with bleeding irregularity. These symptoms were improved in the third and the sixth cycles. The percent-
age of women with spotting or bleeding increased after first cycle, compared with baseline and gradually
decreased during subsequent cycles. After the sixth cycle of treatment, all subjects had improvement of acne.
80% of cases recovered from acne and there were only 20% had mild acne.
Conclusion : Facial seborrhea and acne improved significantly with Oilezz(cid:31).It is good to control cycle without
change in body weight and blood pressure. Therefore, Oilezz(cid:31) can be used for treatment of seborrhea and acne
and as a contraceptive.
Keywords : Biphasic oral contraceptive, Acne, Seborrhea grades, Sebutape
