The Results of Amniotic Membrane Transplantation for Symptomatic Bullous Keratopathy
Orathai Chansanti MD*, Orasa Horatanaruang MD*
Affiliation : * Department of Ophthalmology, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla
Objectives : To evaluate the outcomes of amniotic membrane transplantation for symptomatic relief in patients
with bullous keratopathy.
Materials and Methods : This retrospective study included 17 eyes (17 patients) with bullous keratopathy
presenting with intractable pain or discomfort. The patients were enrolled from January 2000 to December
2004. Amniotic membrane transplantation was performed. Symptomatic relief, epithelial healing, and visual
changes were analyzed.
Results : During the follow up period of 14.1 + 11.9 months (range 1-36 months) after amniotic membrane
transplantation, 14 eyes of 17 eyes (82.4%) with intolerable pain preoperatively had pain relief postopera-
tively. Corneal epithelial healing was complete in all except 2 eyes one of which had evisceration because of
severe corneal ulcer, and the other underwent penetrating keratoplasty soon after amniotic membrane trans-
plantation.
Conclusion : Amniotic membrane transplantation is a safe and effective treatment modality for pain relief
associated with chronic bullous keratopathy. It can be an alternative to conjunctival flap, with better cosmetic
appearance for the management of patients with bullous keratopathy.
Keywords : Bullous keratopathy, Amniotic membrane transplant
