Malignant Ovarian Germ Cell Tumor in King Chulalongkorn Memorial Hospital Ruangsak Lertkhachonsuk MD*, Wichai Termrungruanglert MD*, Apichai Vasuratna MD*, Tul Sittisomwong MD*, Pongkasem Worasethsin MD*, Damrong Tresukosol MD* * Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University
Objectives : To determine the frequency, characteristics, treatment and outcome of patients with malignant
ovarian germ cell tumor (MOGCT) in King Chulalongkorn Memorial Hospital during the period January
1992 – December 2000.
Study
Design : Retrospective descriptive study
Materials and Methods : All patients with malignant ovarian germ cell tumor in King Chulalongkorn Memorial
Hospital during the period January 1992 – December 2000 were analyzed by the characteristics of patients,
treatment and outcome.
Results : Sixty-six patients with MOGCT were demonstrated in that period with a mean age of 22.6 years old.
Most of the patients were nulliparous and premenopausal status. Primary surgery was done in all patients.
Forty-two patients (63.6%) received conservative surgery. Eight patients received no adjuvant treatment after
surgery due to stage IA dysgerminoma and immature teratoma stage I grade I. Fifty-six patients received
chemotherapy for adjuvant treatment. VAC regimen was given in 27 cases (40.9%) and PVB regimen was
given in 25 cases (37.9%). Salvage therapy in the patients with persistent and recurrent disease was treated
in 9 patients, who received a platinum-base of regimen. Two-year survival was 88% with the median time to
follow up 24 months. Overall five-year survival in the present study was 85%.
Conclusion : MOGCT in King Chulalongkorn Memorial Hospital had clinical characteristics similar to other
studies in malignant ovarian germ cell tumor. Treatment by VAC regimen still has benefit in selected group.
Affiliation :
Malignant ovarian germ cell tumor, Survival
Keywords :
