Dementia and Depression in End Stage Renal Disease: Comparison between Hemodialysis and Continuous Ambulatory Peritoneal Dialysis
Pasiri Sithinamsuwan MD*, Suchada Niyasom MD*, Samart Nidhinandana MD*, Ouppatham Supasyndh MD**
Affiliation : * Division of Neurology, Department of Medicine, Phramongkutklao Hospital ** Division of Nephrology, Department of Medicine, Phramongkutklao Hospital
Objectives : To determine the prevalence, risk factors of dementia and depression in end stage renal
disease (ESRD) who were treated with hemodialysis (HD) compared with those who had continuous
ambulatory peritoneal dialysis (CAPD).
Materials and Methods : A cross-sectional study was conducted on 90 ESRD patients (60 HD and 30 CAPD
groups). The authors reviewed the demographic data, investigation results. Thai Mental State Examination,
DSM IV criteria and Thai Depression Inventory were interviewed to determine dementia and depression
respectively.
Results : Both prevalence of dementia and depression in ESRD on continuous dialysis were 6.7 %. In the
HD group had 8.3% prevalence of dementia and 6.7% of depression, whereas there was 3.3% of
dementia and 6.7% of depression in the CAPD group. The severity of depression in the present study
was mild to moderate (6.7%) and no major depression was seen. The significant risk factors for dementia
were age ≥ 60 years (p=0.003), Education < 10 years (p=0.037) and female sex (p=0.036). The
significant risk factor for depression was female sex (p=0.036). There was no significance different on
prevalence of dementia and depression comparison between the HD and CAPD group.
Conclusion : Prevalence of dementia and depression in the overall dialysis in ESRD was 6.7% (with
8.3%, 6.7% among the HD group and 3.3%, 6.7% among CAPD group). There was no significant
difference on prevalence of dementia and depression comparison between the HD and CAPD group.
Keywords : End stage renal disease, Hemodialysis, CAPD peritoneal dialysis, Dementia, Depression
