Urinary Symptoms and Quality of Life Changes in Thai Women with Overactive Bladder after Tolterodine Treatment
Suvit Bunyavejchevin MD, MHS*
Affiliation : * Urogynecology Unit, Department of Obstetric and Gynecology, Faculty of Medicine, Chulalongkorn University
Objectives : To study the urinary symptoms and quality of life changes in Thai women with overactive bladder
(OAB) after tolterodine treatment.
Materials and Methods : Thirty women (aged 30-77 years) diagnosed as having OAB at the Gynecology Clinic,
King Chulalongkorn Memorial Hospital from January to April 2004 were included in the present study.
Tolterodine 2 mg, twice daily was given. After 8 weeks treatment, changes in micturition diary variables and
tolerability were determined. Short form 36 (SF36) questionaires (Thai version) were given before and after
8 weeks of treatment.
Results : At 8 weeks, all micturition per day decreased from 16.7 + 5.3 to 6.7 + 2.4 times per day. The number
of nocturia episodes decreased from 5.4 + 4.2 to 1.1 + 1.0 times per night. The most common side effect was dry
month in 5 cases (16.7%) with 2 cases reporting a moderate degree and 1 case with severe degree. Only one
case (3.3%) withdrew from the present study due to a severe dry mouth. The SF-36 scores changed signifi-
cantly in the domains of physical functioning, role function emotional, social function and mental heath.
Conclusion : Tolterodine was well tolerated and its effects improved the quality of life in Thai women with
OAB.
Keywords : Tolterodine, Overactive bladder, Quality of life
