Radiologic Features and Treatment Outcomes of Pulmonary Metastasis in Gestational Trophoblastic Neoplasia
Prapaporn Suprasert, MD*, Juntima Eua-throngchit, MD**, Jatupol Srisomboon, MD*, Kittipat Charoenkwan, MD*, Sitthicha Siriaree, MD*, Chailert Phongnarisorn, MD*
Affiliation : * Department of Obstetrics and Gynecolgy, Faculty of Medicine, Chiang Mai University, Chiang Mai ** Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai
Objective : To evaluate the radiologic patterns and treatment outcome of pulmonary metastasis in patients
with gestational trophoblastic tumor (GTT).
Materials and Methods : The medical records and chest films of GTT patients treated at Chiang Mai University
Hospital between January 1998 and June 2003 were reviewed.
Results : There were 85 GTT-patients in the study period. 32 cases (37.6%) had pulmonary metastasis diagnosed
with chest X-rays. The most common radiologic pattern was well defined nodule. The radiologic features of
patients who had lung metastases alone were not significantly different from those who had associated
metastases in other organs. 27 patients (84.3%) received multiple chemotherapy and 6 required more than
one regimen. The mean number of chemotherapy was 7 cycles (range 3-23). Adjuvant surgery consisted of
hysterectomy (11), salpingo-oophorectomy (1), thoracotomy (2), and craniotomy (1). Four patients received
whole brain irradiation for brain metastases. Among 10 patients with lung metastasis alone, 8 (80%) attained
complete remission, the remaining 2 patients were lost to follow-up. Among 22 patients with associated
multiple organ metastases, 16 (72.7%) had complete remission, 2 died from diseases, 4 were lost to follow-up.
Conclusion : The most common radiologic pattern of pulmonary metastasis in GTT patients was well-defined
multiple lung nodules. The radiologic features of patients who had lung metastases alone were not significantly
different from those who developed metastases in other organs.
Keywords : Trophoblastic disease, Pulmonary metastasis, Treatment, prognosis
