Recovery Time and Complications of Propofol-Based Deep Sedation for Endoscopic Ultrasonography: A Comparison between With and Without Topical Pharyngeal Anesthesia
Naruenart Lomarattana MD*, Thotsaporn Silapadech MD*, Saipin Muangman MD*, Warunee Boayam BN*, Kanittha Kriprasit BN*, Pathomporn Boonnark BN*, Somchai Amornyotin MD*
Affiliation : * Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Objective : The study is aimed to compare the recovery time and sedation-related complication in propofol-based deep
sedation (PBDS) with and without topical pharyngeal anesthesia for EUS procedures in adult Thai population.
Material and Method: Thirty-two adult patients undergoing EUS procedures were equally randomly assigned to receive
pharyngeal topicalized either with lidocaine spray (Group L) or normal saline (Group N). All patients were premedicated
with 1 mcg/kg of fentanyl and 0.02 mg/kg of midazolam. PBDS was maintained with continuous propofol infusion. Recovery
time using postanesthetic recovery score and discharge score as well as sedation-related complications were evaluated. Total
doses of propofol, fentanyl and midazolam as well as arterial blood pressure values were also recorded.
Results : All EUS procedures were completely successful. There were no significant differences in gender, age, body mass
index, ASA physical status, duration of procedure and indications of procedure between the two groups. The recovery time,
respiratory-related complications, and total doses of propofol, fentanyl and midazolam in both groups were not significantly
different. Hypotension in group L was significantly greater than in group N. In addition, hypertension in group L was
significantly lower than in group N. However, these complications were transient and easily treated.
Conclusion : Addition of topical pharyngeal anesthesia in PBDS technique did not promote the recovery time and not increase
the complication rate during and after EUS procedure. PBDS in both regimens provided effective and safe for EUS. No
serious complications were noted.
Keywords : Recovery time, Complication, Propofol, Endoscopic Ultrasonography, Topical pharyngeal anesthesia
