Effect of Thunbergia laurifolia Lindl. Extract on Anti-Inflammatory, Analgesic and Antipyretic Activity
Urarat Nanna MS*, Natthakarn Chiruntanat PhD**, Kanjana Jaijoy PhD***, Piyanuch Rojsanga PhD****, Seewaboon Sireeratawong PhD**
Affiliation : * Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rungsit Campus, Khlongluang, Pathumthani, Thailand ** Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand *** McCormick Faculty of Nursing, Payap University, Chiang Mai, Thailand **** Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
Background : Thunbergia laurifolia Lindl. belongs to the family Acanthaceae commonly known as Rang jeud in Thailand.
This plant is traditionally used in Thailand for centuries as an antidote for several poisons and drug overdose.
Objective : This research aimed to study the anti-inflammatory, analgesic and antipyretic activities of T. laurifolia water
extract by using animal models.
Material and Method: The anti-inflammatory study was conducted by 3 experiments in animal models namely ethyl
phenylpropiolate (EPP)-induced ear edema, carrageenan or arachidonic acid-induced paw edema and cotton pellet-induced
granuloma formation. The analgesic activity was studies using 2 methods of pain induction including acetic acid and heat
induced pain. Finally, the antipyretic activity study was performed by yeast-induced hyperthermia.
Results : The results showed that the administration of T. laurifolia extract possessed acute anti-inflammatory effects in EPP-
induced ear edema and carrageenan or arachidonic acid-induced paw edema. The extract showed the analgesic activity by
reducing acetic acid-induced writhing response and heat-induced pain as well as showed antipyretic activity by decreasing
body temperature of hyperthermic rats induced by brewer’s yeast.
Conclusion : The study indicates that the T. laurifolia extract possesses the anti-inflammatory, analgesic and antipyretic
activities in animals.
Keywords : Thunbergia laurifolia extract, Anti-inflammatory activity, Analgesic activity, Antipyretic activity
