The Incidence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Patients with Intracranial Aneurysms
Luckchai Phonwijit MD*, Passakorn Prateepawanich MD*, Parunut Itthimathin MD*, Bunpot Sitthinamsuwan MD*, Thaweesak Aurboonyawat MD*, Prajak Srirabheebhat MD*
Affiliation : * Division of Neurosurgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background : There has been no previous study about the incidence of autosomal dominant polycystic kidney disease
(ADPKD) and factors predicting possibility of ADPKD in patients with intracranial aneurysms.
Objective : To investigate the incidence of ADPKD in patients with intracranial aneurysms and predictive factor of ADPKD to
screen and treat patients and family members who may have hidden abnormal genes of this disease.
Material and Method: This is a retrospective study which recruited patients with intracranial aneurysms who underwent
abdominal imaging study, including ultrasonography (USG) or computerized tomography (CT). The incidence of ADPKD
and factor predicting this disease were investigated.
Results : Of 94 patients with intracranial aneurysms, the incidence of ADPKD was 8.5%. Factors predicting ADPKD included
high serum creatinine level and male gender. There was no significant difference in age, incidence of hypertension and
diabetes mellitus between intracranial aneurysm patients with and without ADPKD.
Conclusion : The present authors recommend performing abdominal USG in patients with intracranial aneurysms for
screening ADPKD because USG is non-invasive, inexpensive and useful in treatment and prevention of consequence of this
disease in patients and family members who may have the abnormal genes.
Keywords : Autosomal dominant polycystic kidney disease, ADPKD, Incidence, Predictive factor, Serum creatinine
