Wound Healing Activity of Lawsoniainermis Linn in Rat Model
Sitthichoke Taweepraditpol MD*, Vitusinee U-dee MD*, Sriprasit Boonvisut MD*, Apirag Chuangsuwanich MD*, Kanaporn Pradniwat MD**
Affiliation : * Division of Plastic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background : Wound healing is the repairing process following the injury to the skin and soft tissues. Many kinds of wound
dressings and agents are used for promoting the wound healing process.
Objective : To evaluate the effect of Lawsoniainermis Linn. A herbal extraction, in wound healing process.
Material and Method: In the present study Twenty Sprague Dawley rats were equally random into 4 groups. Each group
were created similar excisional wound model and received 4 different kinds of wound dressings including Lawsoniainermis
Linn., Silver Zinc sulfadiazine and hydrogel. We compared wound size reduction and rate of epithelalization and also studied
histological change of the wound.
Results : The wound size reduction and rate of epithelialiazation were significantly better in Lawsoniainermis Linn comparing
to the other groups. Also, Histological study showed a significant increase in collagen and fibroblasts and decrease inflammatory
cells.
Conclusion : Lawsoniainermis Linn can promote the process of wound healing in animal model and should be further studied
in the future.
Keywords : Lawsoniainermis Linn, Wound healing
