Anti-inflammatory Activities of Extracts of Cinnamomum porrectum (Roxb.) Kosterm. Wood (Thep-tha-ro)
Piangpen Pukdeekumjorn BATM*, Srisopa Ruangnoo PhD**,***, Arunporn Itharat PhD**,***
Affiliation : * Master student of science (Applied Thai Traditional Medicine), Faculty of Medicine, Thammasat University, Pathumthani, Thailand ** Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand *** Center of excellence on Applied Thai Traditional Medicine research (CEATMR), Faculty of Medicine, Thammasat University, Pathumthani, Thailand
Background : Cinnamomum porrectum (Roxb.) Kosterm. (Thai name Thep-tha-ro) is a medicinal and aromatic tree mostly
distributed throughout southern Thailand. It is traditionally used as spices, vegetable, carminative, tonic, febrifuge and
postpartum care for being anti-inflammation whilst chemical components and its anti-inflammatory activity of this plant
extracts were rarely reported.
Objective : To investigate the anti-inflammatory activity of the crude extracts from different extraction method of C. porrectum
wood.
Material and Method: Steam distillation, maceration in 50% or 95% ethanol or decoction method were used for extraction.
The extracts were obtained as oil, ethanolic or aqueous extracts, respectively. These extracts were tested in vitro for anti-
inflammatory activity using nitric inhibitory assay by determining the inhibitory activity on lipopolysaccharide (LPS) induced
nitric oxide production in RAW 264.7 cell lines.
Results : The 50%, 95% ethanolic extracts of this plant showed high anti-inflammatory activity (IC50 values as 19.28+2.43
and 13.78+3.76 μg/ml, respectively), where water extract of this plant showed low anti-inflammatory activity (IC50 values
>100 μg/ml), oily extracts showed cytotoxicity.
Conclusion : The results revealed that ethanolic extracts showed strong anti-inflammatory activity; therefore these extracts
of Cinnamomum porrectum should be further developed as a health product for treatment of inflammation.
Keywords : Anti-inflammatory activity, Cinnamomum porrectum, Thep-ta-ro, Nitric oxide, Ethanolic extracts
