The Association of Bone Mineral Density and G2014A Polymorphism in the Estrogen Receptor Alpha Gene in Osteoporotic Hip Fracture in Thai Population
Wiwat Wajanavisit MD*, Sakda Suppachokmongkorn MD*, Patarawan Woratanarat MD, PhD*, Boonsong Ongphiphadhanakul MD**, Tulyapruek Tawonsawatruk MD, PhD*
Affiliation : * Department of Orthopedic, Faculty of Medicine, Ramathibodi Hospital Mahidol University, Bangkok, Thailand ** Department of Medicine, Faculty of Medicine, Ramathibodi Hospital Mahidol University, Bangkok, Thailand
Objective : This study aimed to determine the association of a recent identified G2014A single nucleotide polymorphism (SNP)
genotype distribution in exon 8 of the estrogen receptor in postmenopausal Thai women.
Material and Method: A prospective study was conducted at Ramathibodi Hospital between July 2005 and July 2006.
Postmenopausal Thai women, aged more than 55 years and had sustained osteoporotic hip fracture, were included. Exclusion
criteria were renal and metabolic bone diseases. Age, body mass index (BMI), blood tests for metabolic bone disease, and
G2014A SNP genotype, bone mineral density (BMD) were collected. The relationship between the degree of osteoporosis
(normal, osteopenia, and osteoporosis) and SNP genotype was analyzed by Fisher’s exact test.
Results : Sixty-five postmenopausal women with osteoporosis were included. The average age was 76.2+10.9 years old, and
the average BMI was 21.3+3.5 kg/m2. The data expressing the genotype distribution of gene G2014A SNP were G/G 23.1%,
G/A 29.2% and A/A 47.7%. There was no statistical difference between age and BMI in each genotype. Gene G2014A was
associated with osteoporosis of lumbar spine, femoral neck, ward triangle, and femoral neck.
Conclusion : It could be concluded that a G2014A SNP genotype in exon 8 of the estrogen receptor was associated with
postmenopausal women who had osteoporotic hip fracture.
Keywords : Osteoporosis, Hip fracture, Estrogen receptor, G2014A, Thai
