Effect of Tri-Sa-Maw Recipe on Gastrointestinal Regulation and Motility
Supaporn Wannasiri MS*, Kanjana Jaijoy PhD**, Natthakarn Chiranthanut PhD***, Noppamas Soonthornchareonnon PhD****, Seewaboon Sireeratawong PhD***,*****
Affiliation : * Division of Physiology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani, Thailand ** McCormick Faculty of Nursing, Payap University, Chiang Mai, Thailand *** Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand **** Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. ***** Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rungsit Campus, Pathumthani, Thailand
Background : Tri-sa-maw recipe is comprised of equal proportions of three herbal fruits, including Terminalia chebula Retz.,
Terminalia sp. and Terminalia bellirica Roxb. The traditional use of this recipe has been reported as a medication for fever,
expectorant, relief of tightness in the stomach, laxative and antidiarrheal agent.
Objective : To study the effects of Tri-sa-maw recipe extract on gastrointestinal tract in both in vitro and in vivo.
Material and Method: Gastrointestinal effect of Tri-sa-maw recipe was studied by using two in vivo models (gastric
emptying, gastrointestinal transit) and in vitro isolated guinea pig ileum experiment.
Results : Tri-sa-maw recipe showed both stimulatory and inhibitory effects on the stomach function. Not only did the extract at
the dose of 1,000 mg/kg inhibit the gastric emptying time, but also stimulate the movement of the digestive tract by increasing
the mobility of charcoal. In the isolated guinea pig ileum experiment, the extract at low concentration (0.1 ng/mL) induced the
contraction of isolated guinea pig ileum. However, the stimulation effect on contractions of isolated guinea pig ileum was very
much decreased at the high concentration (0.2-1 ng/mL) of the extract.
Conclusion : The findings of this study support to traditional uses of Tri-sa-maw recipe as a laxative and antidiarrheal agent.
Keywords : Tri-sa-maw recipe, Gastric emptying, Intestinal transit
