Normal Range of Serum Highly-Sensitive Troponin-T in Patients with Chronic Kidney Disease Stage 3-5
Thunnop Chotivanawan MD*, Rungroj Krittayaphong MD*
Affiliation : * Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background : Serum troponin-T concentrations are commonly increased in chronic kidney disease (CKD) without acute
coronary syndrome. Highly-sensitive troponin-T, the new tool that helpful for diagnosis of acute coronary syndrome,
provides few data about normal value in patients with chronic kidney disease.
Material and Method: The authors studied 89 patients with CKD stage 3-5: 40 had CKD stage 3, 26 had CKD stage 4 and
23 had CKD stage 5. Serum samples were collected for the analysis of highly-sensitive troponin-T levels. The values of highly-
sensitive troponin-T of the total group and each CKD stage were presented.
Results : The level of highly-sensitive troponin-T in patients with CKD stage 3-5 was 0.044 + 0.076 ng/ml. For CKD stages
3, 4 and 5 levels were 0.015 + 0.016, 0.043 + 0.056, 0.098 + 0.121 ng/ml, respectively. 95th percentile of the total group was
0.139 ng/ml. 95th percentile for stage 3, 4 and 5 were 0.052, 0.136, 0.297 ng/ml, respectively.
Conclusion : 95th percentile for highly-sensitive troponin-T of patients with CKD stage 3-5 was 0.139 ng/ml. This number
may be considered as the cut-off value for diagnosis of acute myocardial infarction.
Keywords : Troponin-T, Chronic kidney disease, Acute coronary syndrome, High sensitive
