Objective: To investigate the effect of frailty regarding frail versus non-frail patients with carotid artery stenosis.

Materials and Methods: The present study was a retrospective cohort study performed in a tertiary care setting. The study included the baseline characteristics and clinical outcomes of the participants. Univariate analysis and Cox proportional hazard regression model were used to include confounders. The primary outcome was the composite of the ischemic stroke and all-caused death in frail versus non-frail patients with carotid artery stenosis.

Results: The present study included 450 patients with a 1-year follow-up. Composite events occurred in 33 patients (22.0%) in the frailty with carotid artery stenosis group compared with 35 patients (11.7%) in non-frailty with carotid artery stenosis group (HR 1.92, 95% CI 1.59 to 2.37, p<0.001).

Conclusion: Frailty is strongly associated with unfavorable outcomes in older patients with carotid artery stenosis. Risk stratification and special consideration in frail older patients should be considered in the strategy plan of care.

Received 11 January 2024 | Revised 8 May 2024 | Accepted 14 May 2024

DOI:10.35755/jmedassocthai.2024.7.14009