Subacute Sclerosing Panencephalitis in Immunized Thai Children
Khanittha Khusiwilai MD*, Sorawit Viravan MD**
Affiliation : * Division of Neurology, Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumtani, Thailand ** Division of Neurology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Subacute sclerosing panencephalitis (SSPE) is a progressive neurodegenerative disease with high mortality and poor prognosis. This is caused by persistent defective measles virus infection. Clinical presentations are variable including behavioral-cognitive change, myoclonic seizure, visual problem, spasticity or abnormal movement. The authors report a case of 10 year-old boy, previously healthy with complete immunization, presenting with frequent myoclonic jerks, abnormal movements, spasticity and altered mental status. Electroencephalographic (EEG), magnetic resonance imaging (MRI), and laboratory findings are typical for SSPE.
Keywords : SSPE, Measles, Vaccine, Subclinical infection
