The Reality of Osteocalcin as a Marker of Vitamin K2
Narong Bunyaratavej MD*, Shutipen Buranasinsup BSc, PhD**, Arunee Jangsangthong BS**
Affiliation : * Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Department of Pre-clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Nakornpathom, Thailand
The present study showed the correlation between undercarboxylated osteocalcin and vitamin D had a role in production of the undercarboxylated osteocalcin, when the amount of vitamin D 25 (OH) D, (below 30 ng/ml) was decreased, the linear correlation (r) between the vitamin D and undercarboxylated osteocalcin were also decreased, r = 0.032 when the level of vitamin D was risen, the linear correlation was 0.274,unfortunately the study-population had little group of the normal level of vitamin D due to most of them were vitamin D insufficiency so the authors could not show the more value of ‘r’. However, the present study confirmed that the role of vitamin D in formation of undercarboxylated osteocalcin (UcOC) which we recognized the UcOC at the low level of vitamin D will misinterpretation of the level of vitamin K2.
Keywords : Osteocalcin, Vitamin K2, Undercarboxylated-Osteocalcin
