Osteoblastic Functions: A Lesson from Biochemical Bone Markers
Narong Bunyaratavej MD*
Affiliation : * Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand
The present study showed the lowest values of bone markers from osteoblast, NMID osteocalcin, 10.81 + 3.9 ng/ ml and PINP 15.88 + 7.09 ng/ml at lowest level of osteoclast, betaCTx, 0.066 + 0.22 ng/ml should be the cut value for osteoblastic function. At this level betaCTx, had no correlation with PINP (r = 0.198, p = 0.003) or NMID osteocalcin (r = 0.035, p = 0.606) compared to the normal value of the control group and the correlation (r) between betaCTx and NMID osteocalcin, betaCTx and PINP, which were 0.757 and 0.752 (p = 0.001) respectively and recognized as normal bone turnover with coupling effect. So, bone markers of osteoblast at the lowest value of betaCTx (0.066 ng/ml) with NMID osteocalcin, 10.81 + 3.9 ng/ml and PINP 15.887.09 ng/ml may be the cut value of osteoblast reflecting poor functions. The benefit of identifying the cut values of osteoblast will help in making decisions in osteoporotic management.
Keywords : Osteoblastic function, PINP, BetaCTx (betacrosslap), NMID-osteocalcin
