Study of Validity of Pyridinoline and Correlation of Pyridinoline and Beta Crosslap in Postmenopausal Women
Narong Bunyaratavej MD*, Shutipen Buranasinsup PhD**
Affiliation : * Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Department of Pre-clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Nakornpathom, Thailand
This research studied the validity and correlation of β-CTx (Betacrosslap) and Pyridinoline (PYD) in 71 cases of postmenopausal Thai women who attended at the osteoporosis clinic. The validity consisted of sensitivity, specificity and accuracy of PYD. They were 53.44, 84.6 and 59.15 % respectively. So, the validity of pyridinoline test was rather poor and the correlation between betacrosslap and pyridinoline was weak (r = 0.123, p = 0.0001) which was not significant in practice. In conclusion, the pyridinoline test was not proper for bone resorption even pyridinoline was abundant in bone.
Keywords : Pyridinoline (PYD), BetacrossLap, betaCTx, Validity
