Report 2 Cases of Congenital Factor XII Deficiency: A Rare Coagulation Disorder
Somjai Kanjanapongkul MD*
Affiliation : * Hemato/Oncology Unit. Queen Sirikit National Institute of Child Health, College of Medicine, Rangsit University, Bangkok, Thailand
Factor XII (F.XII, Hageman factor) is one of the contact system factors which initiates an intrinsic coagulation pathway. But its definite role is still unclear, because many cases of severe F.XII deficiency experience thrombotic events instead of a bleeding problem. Moreover, most of them are asymptomatic. There have only been a few reports of F.XII deficiency in Thailand. The author reports two cases of congenital F. XII deficiency in Thai children.
Keywords : Prolonged aPTT, Factor XII deficiency, Thrombosis
