Predictive Factors for Survival Time of 273 Inoperable Hilar Cholangiocarcinoma Patients: Disease Registry Analyses
Srikhajonjit S, MD1, Mairiang P, MD1, Mairiang E, MD2, Sawadpanitch K, MD1, Sangchan A, MD1, Sukeepaisarnjaroen W, MD1, Chunlertrith K, MD1
Affiliation : 1 Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand 2 Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Background : Cholangiocarcinoma (CCA) is a rare primary liver cancer in most parts of the world; however, it is the major liver
cancer in the Northeast region of Thailand. Hilar cholangiocarcinoma (HCA), is the most common type of CCA, commonly presents
with cholestasis; a majority of HCA is in an inoperable stage. This study aimed to analyze factors that predict survival of inoperable
HCA in the high patient-loaded-center.
Materials and Methods : The study analyzed the data from hilar cholangiocarcinoma registry of 273 HCA. The survival time (Kaplan-
Meier) was analyzed in association with age, sex, underlying diseases, liver function tests, level of CEA and CA19-9, Bismuth-
Corlette type, staging and methods of treatment. Univariate and multivariate analyses were performed.
Results : The poor prognostic factors were clinical presentation with jaundice, ECOG performance status >3, serum CA19-9 >100
U/mL, serum CEA >30 ng/mL. Patients who had biliary drainage with ERCP and PTBD had reduced risk of death (hazard ratio [HR]
0.48, 95% confidence interval [CI] 0.25 to 0.90 and HR 0.40, 95% CI 0.24 to 0.69, respectively).
Conclusion : Inoperable HCA has poor prognosis. Biliary drainage with either ERCP or PTBD can prolong the survival time.
Keywords : Hilar cholangiocarcinoma, Survival analyses, Prognostic factors
