Prevalence and Factors Related to Failure to Receive Hormonal Replacement Therapy after Bilateral Oophorectomy in Women Aged 45 Years or Younger
Ngernyaem S, MD1, Ratchanon S, MD2
Affiliation : 1 Department of Obstetrics and Gynecology, Samitivej Chonburi Hospital, Chonburi, Thailand 2 Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Objective : To determine the prevalence and factors related to failure to receive hormonal replacement therapy (HRT) after bilateral
oophorectomy in women aged 45 years or younger.
Materials and Methods: A retrospective descriptive study was conducted in patients who underwent bilateral oophorectomy
during January 2009 to December 2013 in Faculty of Medicine Vajira Hospital. Inclusion criteria were age 18 to 45 years old had
complete ovarian tissue removed. Exclusion criteria were women who had contraindication to HRT.
Results : A total of 183 patients had some types of gynecologic surgery including bilateral oophorectomy during the study period.
Eighteen patients were excluded due to the following contraindications: incomplete ovarian removal (9 patients), history of breast
cancer (5 patients) or deep vein thrombosis (4 patients). The median age of 165 patients included in the study was 40.6 years (range
24 to 45 years) with the median BMI of 24.3 kg/m2 (range 23.8 to 40.2 kg/m2). The most common indication for surgery was
adenomyosis with or without endometriosis (54.5%). The prevalence of failure to receive HRT was 52.7%. Factors significantly
related to failure were having gynecologic malignancy and age older than 40 years.
Conclusion : Slightly more than half of the patients, aged younger than 45 years, who had undergone bilateral oophorectomy failed
to receive HRT. Significantly related factors were gynecologic malignancy and age older than 40 years.
Keywords : Surgical menopause, Bilateral oophorectomy, Hormonal replacement therapy
