Recurrent Rates and Risk Factors of Febrile Seizures in the Subsequent Illness Following the First Febrile Seizures in Thai Children
Maksikharin A, MD1, Prommalikit O, MD1
Affiliation : 1 Department of Pediatrics, HRH Princess Maha Chakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
Objective : To determine risk and risk factors of recurrent febrile seizures after first febrile seizures.
Materials and Methods : This was an observational prospective cohort study on children 6 months to 5 years of age who presented
with the first febrile seizures between January 2007 to June 2013. The data was collected from medical records and interviews with
parents.
Results : 357 children were enrolled with the first febrile seizures with a mean (SD) age of 20.9 (12.4) months. 19.3% of these had
recurrent febrile seizures and a cumulative risk of recurrence was 13%, 19% and 19.3% at 12, 24 and 50 months after first febrile
seizures, respectively. By multivariate analysis, family history of febrile seizures was the significant risk factor for recurrence of
febrile seizures (p<0.05). Age, gender, duration of fever before seizures, the temperature at initial seizures, complex febrile seizures,
type of seizures and family history of epilepsy were not associated with risk of recurrent febrile seizures.
Conclusion : The recurrent febrile seizures was more frequent at 12 to 24 months after the first febrile seizures and the positive
family history of febrile seizure was increasing risk of recurrent febrile seizures in subsequent illness.
Keywords : Febrile seizures, Recurrent febrile seizures, Risk of recurrence, Risk
