Liver Transplantation for Hepatic Adenomatosis: The First Case Report in Thailand and Literature Review
Pongphob Intaraprasong MD¹, Taya Kitiyakara MD¹, Napat Angkathunyakul MD² , ³, Duangkamon Prapruttam MD⁴, Chutima Charoenthanakit BNS⁵, Bundit Sakulchairungrueng MD⁶, Goragoch Gesprasert MD⁶, Nuttapon Arpornsujaritkun MD⁶
Affiliation : ¹ Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand ² Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand ³ Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ⁴ Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand ⁵ Nursing Department Queen Sirikit Medical Center, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand ⁶ Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Hepatic adenomas are benign solid liver tumors commonly found in young females and usually asymptomatic. Hepatic adenomatosis is characterized
by more than 10 adenomas in an otherwise normal liver. Bleeding and malignant transformation uncommonly occur especially in tumor larger
than 5 cm and in male patients. The authors reported a case of a young female with large multiple hepatic adenomas from hepatic adenomatosis
that presented with abdominal pain, large abdominal mass, weight lost, and abnormal liver function tests. She failed transarterial embolization.
Surgical resection was not offered due to extent of the hepatic adenomas. She received orthotopic liver transplantation as rescue therapy. Her
explanted liver showed multiple foci of hepatocellular carcinoma (HCC). Her post-operative was uneventful. The authors reported a case of liver
transplantation for the treatment of unresectable hepatic adenomatosis.
Received 29 June 2020 | Revised 14 September 2020 | Accepted 15 September 2020
doi.org/10.35755/jmedassocthai.2021.02.11577
Keywords : Hepatic adenomatosis, Malignant transformation, Liver transplantation
