Mean Platelet Volume (Mpv) as a Predictor of Venous Thromboembolism (Vte) in Colorectal Cancer
Wilasrusmee C, MD1, Wongsereepatana J, MD1, Poprom N, MPh1, Horsirimanont S, MD1, Supsamutchai C, MD1, Jirasiritham J, MD1, Siribumrungwong B, MD2, Phuwapraisirisan S, MD1
Affiliation : 1 Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 2 Department of Surgery, Faculty of Medicine, Thammasat University Hospital, Pathumthani, Thailand
Background : Platelet activity is a major devilish atherothrombotic events and cancer. Mean platelet volume (MPV), which is widely
available as a routine parameter of the complete blood count, is a potentially useful biomarker of platelet activity in the setting of
venous thrombosis. Recent studies showed that high-MPV levels are associated with an increase VTE risk in cancer patients.
Objective : To investigate the role of MPV in VTE and colorectal-cancer.
Materials and Methods : A retrospective study was performed to analyze differences of MPV between patients with VTE, VTE and
colorectal-cancer, and control.
We identified comparative studies that compared the effect of MPV in VTE from PubMed and Scopus databases up to
December 2017. Two reviewers independently extracted data for meta-analysis. Differences in MPV were expressed as unstandardized
mean difference.
Results : Among 170 patients, 58-control, 54-VTE, and 58-VTE with colorectal-cancer, MPV was significantly higher in VTE groups.
From 403 articles, 10 studies (5 cohorts and 5 case-controls) comprising 2,265 patients. MPV was significantly higher in those with
VTE (mean difference 0.61 fL, 95% CI 0.34 to 0.88, p<0.001). Elevated MPV increased the relative risk of VTE (RR 1.319, 1.061 to
1.641, I2 = 82.5%).
Conclusion : Our evidence suggests that elevated MPV is associated with VTE and VTE with colorectal-cancer. A mechanistic study
and RCT are required in order to use antiplatelet therapy.
Keywords : Deep vein thrombosis, Meta-analysis, Pulmonary embolism
