Treatment Outcomes of Cervical Carcinoma in HIV-infected Patients
Kanisa Rongsriyam MD1, Thanatip Tantivatana MD1
Affiliation : 1 Division of Radiation Oncology, Department of Radiology, faculty of Medicine Vajira Hospital, Navamindrahiraj University, Bangkok, Thailand
Objective : To evaluate treatment outcomes, treatment toxicities and determine prognostic factors of treated cervical cancer in
human immunodeficiency virus [HIV]-infected patients.
Materials and Methods : A retrospective analysis of cervical cancer in HIV-infected patients who were treated in Radiation
oncology Unit, Department of radiology, Faculty of Medicine Vajira Hospital between 2003 and 2017. The Kaplan-Meier
method was used for survival analysis. The authors analyzed association of patients and tumor characteristics with survival
using the log-rank test and Cox models.
Results : A total of 131 cervical cancers in HIV-infected patients were included. Eighty-one patients (61.8%) were previously
diagnosed with acquired immune deficiency syndrome [AIDS] and treated with antiretroviral therapy [ART], the rest of the
patients (38.2%) were diagnosed to AIDS and commenced an ART at the diagnosis of cervical cancer. The 2-year and 5-year
DFS were 88.2% and 79.5%, respectively. The corresponding 2-year and 5-year overall survival were 83.8% and 78.7%,
respectively. Characteristics associated with a decrease of survival which is statistically significant include grade, stage and
a lack of ART during cancer treatment. Treatment toxicities ranged from 0.8% to 8.2%. Majority of the complications were
mainly grade 1 or 2. Severe late toxicity (2.3%) was found only in Genito-urinary system.
Conclusion : Cervical cancer in HIV-infected patients who were treated with ART and cancer treatment had a favorable
survival outcome and toxicity. Grade and stage of cancer significantly affect the survival outcome.
Keywords : Cervical cancer, AIDS, HIV, Treatment outcome, Antiretroviral
