Long-Term Outcomes after Concurrent Chemoradiotherapy in Cervical Cancer
Thanatip Tantivatana MD1, Kanisa Rongsriyam MD1, Marisa Chongthanakorn MD1, Kamonrat Sueangamiam MSc1
Affiliation : 1 Division of Radiation Oncology, Department of Radiology, faculty of Medicine Vajira Hospital, Navamindrahiraj University, Bangkok, Thailand
Objective : To assess long-term survival outcomes and to identify prognostic factors for patients with cervical cancer treated
with concurrent chemoradiotherapy [CCRT].
Materials and Methods : Cervical cancer patients who had CCRT in the Radiation oncology Unit, Department of Radiology,
Faculty of Medicine Vajira Hospital between 2001 and 2017 were identified. Survival rate of the patients was analyzed by
Kaplan-Meier method. Association between clinic-pathologic factors and survival were also studied using the log-rank test
and Cox models.
Results : A total of 1310 cervical cancer patients were included in this study. The 5-year and 10-year disease free survival rates
were 71.7% and 70.5%, respectively. The corresponding-5-year and 10-year overall survival rates were 74% and 68.5%,
respectively. The 10-year overall survival decreased as stage advanced from 83.1% in stage I to 77.1%, 56.3% and 49.6 in
stage II, III and IV, respectively. The poor factors which significantly associated with a lower survival rate included higher
tumor grade, pre-treatment hemoglobin level <12g/dl, and higher clinical stage.
Conclusion : Cervical cancer patients who were treated with CCRT had a favorable long-term survival outcome. Survival
rates did not change much between 5 and 10 years. Grade, hemoglobin level and clinical stage of cancer were significant
prognostic factors for survival outcome.
Keywords : Cervical cancer, CCRT, Long term outcome
