Factors Associated with Childhood Non-Atopic Asthma
Patchanee Benjasupattananun MD1, Nitchanan Achararit MD2, Manutham Manavathongchai MD2
Affiliation : 1 Department of Pediatrics, Charoenkrung Pracharak Hospital, Bangkok Metropolitan Administration, Bangkok, Thailand 2 Department of Pediatrics, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Objective : To determine factors associated with childhood non-atopic asthma comparing to those with atopic asthma
Materials and Methods : A cross-sectional study was conducted among asthmatic pediatric patients aged between 1 month
and 15 years of age who were treated between 2008 and 2013 at Department of Pediatrics, Charoenkrung Pracharak Hospital.
Positive skin prick test with at least 1 allergen indicated atopic asthma whereas the negative test indictaed non-atopic asthma.
Population characteristics and factors associated with non-atopic asthma were compared with atopic group.
Results : Of 373 childhood asthmatic patients studied, 189 (50.7%) had non-atopic asthma. Median age at onset and medain
age of non-atopic asthmatic patients were significantly younger than atopic asthmatic patients: 1.16+1.29 years vs. 2.18+
1.99 years (p<0.001) and 2.91+2.08 years vs. 5.45+3.33 years (p<0.001), respectively. Factors associated with a significantly
greater risk of non-atopic comparing to atopic asthma included age at onset <1 year old, a history of wheezing associated with
upper respiratory tract infection, and a history of breastfeeding >6 months.
Conclusion : Factors associated with a greater risk of non-atopic asthma were age at onset <1 year old, a history of wheezing
associated with upper respiratory tract infection, and a history of breastfeeding >6 months.
Keywords : Non-atopic asthma, Risk factors
